Pregabalin is a medication related to the neurotransmitter GABA (gamma-aminobutyric acid) and is commonly used to manage nerve pain in dogs and cats. It can be very effective for this purpose. In some cases, pregabalin may also be prescribed as an add-on therapy for epileptic seizures that are difficult to control with standard medications, though success in this area has been limited.
This medication is generally considered very safe, even for long-term or lifelong use when needed. Pregabalin should not be stopped suddenly, as this may increase the risk of seizures or cause pain to return quickly.
Pregabalin is classified as a controlled substance. This means it is regulated and can only be prescribed by a veterinarian with a DEA license.
Dosing
Pregabalin is well absorbed when given orally in both dogs and cats. Because it stays in the body longer than some other medications, it is usually given every 12 hours, making it more convenient for many pet owners. The medication reaches a steady level in the bloodstream within 1–3 days.
Possible Side Effects
Pregabalin is very safe, and most side effects resolve with dose adjustment or stopping the medication:
- Mild sedation: More likely at higher doses or when combined with other sedating medications.
- Mild incoordination: More likely at higher doses or when combined with other sedating medications.
- Gastrointestinal upset: Vomiting or diarrhea may occur but is an uncommon side effect.