Levetiracetam is generally considered a safe and well-tolerated anti-seizure medication for both dogs and cats. It may be used alone or in combination with other anticonvulsants, and can be especially helpful in cases of structural epilepsy (e.g. tumor, stroke, meningitis).
While your pet is on Levetiracetam, we recommend yearly physical and neurologic examinations, along with routine bloodwork (CBC and chemistry panel).
Dosing
This medication has a wide dosing range. Typically, treatment begins at a low to mid-range dose, and the amount is gradually adjusted based on your pet’s seizure control.
- It is very important to give this medication on time, every 8 hours (for example: 7 am, 3 pm, and 11 pm).
- An extended-release form (Keppra XR) is available that can be given every 12 hours. However, due to the available tablet sizes, not all pets are eligible for this option.
- Do not confuse the immediate-release and extended-release forms, as giving the wrong one can lead to worsening seizure control.
Possible Side Effects
Levetiracetam is considered a very safe medication, and side effects are usually mild if they occur. Possible side effects include:
- Mild, temporary sedation or wobbliness: Some pets may seem sleepy or uncoordinated at first. This usually improves within about two weeks as they adjust.
- Digestive upset: Possible side effects include decreased appetite, vomiting, or diarrhea.
- Behavioral changes: Rarely, some dogs may show increased irritability or aggression.
Additional Information
If your pet is on the extended-release version, you may occasionally see the empty pill casing in their stool. This is normal and means medication has already been absorbed.